Job Description

DMPK (PRE-FORMULATIONS) RESEARCH SCIENTIST Educational qualifications

M.Pharm (Pharmaceutics)/ Ph.D (Pharmacy) Years of experience

8-10 yrs Key Responsibilities
?
Read and understand client pre-formulation
requirements ? Solid State and Solution State
Characterization (interpretation of DSC, TGA
and pXRD etc. data) ? Solubility assessment in Aqueous and
Organic solvents simulated intestinal and
gastric Medias. ? Bioavailability enhancement of compounds ? Excipient Compatibility Studies ? Preclinical formulation development of NCEs
for pharmacokinetic, toxicology, & in vivo
efficacy studies. ? Ability to work with wide variety of
excipients, API and dosage forms ? Hands-on experience in strategy to come up
with pharmaceutically acceptable salts for
NCEs and their characterization and
interpretation of the data to propose the
suitable salt. ? Should know the know-how of various
formulations combinations to address the
solubility issues for various routes to perform
PK studies in preclinical species. ? Should be able to develop dosage forms for
therapeutic areas like oncology, metabolic
disorders, inflammation etc. ? Should be able to develop HPLC-UV based
methods for conducting formulation analysis
under GLP and Non-GLP modes ? Good knowledge of chromatography ? Preparation of documents such as SOP's for

DMPK (PRE-FORMULATIONS) RESEARCH SCIENTIST Laboratory instruments and reports for
preformulation studies.

Experience required
?
Good scientific knowledge about the role of
pre-formulation in small molecule discovery. ? Basic knowledge of pharmacokinetics . ? Knowledge of various excipients and their
permissible limits in preclinical and clinical
setups. ? Handling of HPLC-UV/PDA ? Liquid chromatography.