Job Description

Job Title: Senior Scientist - In Vitro Secondary PharmacologyCareer Level: DIntroduction to role:Are you ready to make a significant impact in the world of drug discovery and development? Join AstraZeneca's Clinical Pharmacology & Safety Sciences (CPSS) department, where innovation meets collaboration. Our Safety Innovation team is at the forefront of advancing a diverse pipeline across therapeutic areas, delivering safety science from early discovery through clinical development. We are seeking a talented in vitro pharmacologist to join our Secondary Pharmacology team, contributing to the clinical advancement of new medicines.Accountabilities:In this pivotal role, you'll leverage your expertise in pharmacology, toxicology, and biology to collaborate with drug safety specialists and project safety pharmacologists. Your insights will shape drug design during the early phases of discovery, ensuring the selection of safer molecules and developing strategies to mitigate safety risks. You'll generate in vitro pharmacological profiling data at contract research organizations (CROs), identify off-target risks, and interpret pharmacological interactions. Your work will translate in vitro activity into pre-clinical and clinical adverse events, providing crucial guidance for project decisions.Essential Skills/Experience:

• PhD or Masters or equivalent experience in a relevant scientific field with 4+ years of industrial experience.
• A strong background in pharmacology (e.g., pharmacology, biology, biochemistry, toxicology, physiology) with a proven track record in driving innovative science, preferably in the pharmaceutical or biotechnology industry.
• Technical experience in in vitro pharmacological or biochemical assay development and screening (e.g., kinase profiling technologies, radioligand binding, enzyme activity, and functional cell-based systems) applied to various biological target classes.
• Excellent problem-solving and organisational skills, delivery focus, and outstanding communication skills.
• A true collaborator with highly effective networking skills and experience collaborating across scientific disciplines, cultures, and expertise.

Desirable Skills/Experience:

• Experience with off-target profiling data and strategies in the pharmaceutical industry.
• Practical understanding of kinase profiling technologies.
• Experience working with CROs, commissioning requests and driving delivery processes.
• Experience with being entrepreneurial taking the initiative in projects.
• Demonstrated leadership in scientific projects or teams.
• Experience in regulatory interactions or safety assessments.
• Knowledge of emerging trends in drug safety and pharmacovigilance.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.At AstraZeneca, we are driven by curiosity and courage, exploring what science can achieve. Our commitment to making a difference is unwavering as we fuse data and technology with scientific innovation to tackle some of the world's most complex diseases. We celebrate successes and learn from failures, creating an inclusive environment where diverse knowledge is leveraged for swift impact on disease. With opportunities for lifelong learning and career growth, AstraZeneca is where you can push boundaries and deliver life-changing medicines.Ready to make a difference? Apply now and be part of a team that transforms patient lives through groundbreaking science!Date Posted 23-May-2025Closing Date 03-Jun-2025AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca