Job Description

Job Role



Team Member - Chemical Research & Development





Department



Research & Development





Sub Department



Peptide Synthesis

PURPOSE OF THE ROLE

The objective of the role is to perform chemical synthesis of molecules, the role involves process development, process validation and transfer to production units.

JOB DESCRIPTION

(What the person needs to deliver at workplace)



Literature search and collection of MSDS.

Performing the lab experiments.

Documentation of lab experiments, experimental results and interpretation of spectral data.

Maintenance of documents like patents, literature, analytical reports.

Discussion with analytical chemists and DQA on analytical results and methods. To account for chemical usage and availability of raw materials.

Performing the calibration of lab equipment's like weighing balance, pH meter, and driers.

Performing the lab experiments and updating to immediate supervisor.

Maintaining of lab notebook and documentation of experimental results.

Ensuring the availability of regular solvents reagents and indent to warehouse.

Management of effluent generation from lab experiments.

Round the clock follow up and monitoring the plant batches during process validation.

Perform Manual Solid Phase Peptide Synthesis of Peptides on Medium scale, commercial scale (1 to 10 g, 100 g and 1kg final product) with minimal or no supervision.

Purification of solid phase products, commercial process, CGMP activities, synthesis of impurities, reference standards and degradation impurity standards for analytical method development and validation.

Safety awareness and implementation

Strict adherence to Good Laboratory Practices and Laboratory Safety Norms.

QUALIFICATIONS/ EXPERIENCE REQUIREMENTS

Parameter

Minimum

Preferred

Education



M.Sc. (Organic Chemistry)



M.Sc. (Organic Chemistry)





Experience (in Years)



2



6





Nature of Experience



Prior work experience in R&D Department of an API manufacturing company, knowledge of Process R&D and scale up experience.

COMPETENCY REQUIREMENTS

#

FUNCTIONAL

Functional Knowledge

Coupling Reagents Documentation GLP and safety compliances

Experience

Plant scale-up Solid Phase Synthesis Solution Phase Synthesis Purification

BEHAVIOURAL

Results Orientation





Customer Centricity





Collaboration & Teamwork





Problem Solving





Planning





Communication





Continuous Learning