Job Description

About the job

Jubilant Bhartia Group
Jubilant Bhartia Group is a global conglomerate founded by Mr. Shyam S Bhartia and Mr. Hari S Bhartia with strong presence in diverse sectors like Pharmaceuticals, Contract Research and Development Services, Proprietary Novel Drugs, Life Science Ingredients, Agri Products, Performance Polymers, Food Service (QSR), Food, Auto, Consulting in Aerospace and Oilfield Services. Jubilant Bhartia Group has four flagships Companies- Jubilant Pharmova Limited, Jubilant Ingrevia Limited, Jubilant FoodWorks Limited and Jubilant Industries Limited. Currently the group has a global workforce of around 43,000 employees.
About Jubilant Biosys
Jubilant Biosys Ltd is a part of the Jubilant Pharmova family of companies with RD centres in India and business offices in Asia and North America. With our global reach, Jubilant Biosys provides comprehensive drug discovery services and contract research servicesfrom target discovery to candidate selection and with flexible business models (FFS, FTE and risk shared)in partnership with leading worldwide healthcare companies.
With a clear scientific focus in oncology, metabolic disorders, central nervous system (CNS) diseases, pain and inflammation, Jubilant Biosys has rapidly emerged as a leading collaborator for pharmaceutical and biotechnology companies worldwide. In each of these therapeutic areas, Jubilant Biosys has developed a deep level of expertise in discovery informatics, computational chemistry , medicinal chemistry, structural biology , biology,in-vivo,in-vitromodels and translational sciences. Combined with strong clinical development and manufacturing capabilities from other Jubilant subsidiaries, Jubilant Biosys has risen as a fully integrated contract research organization in India and headquartered at Bengaluru with end-to-end solutions.
Our ability to be the preferred collaborator in the drug discovery domain is sustained by our commitment to comply with and continually improve our quality systems and to provide the following services:
Contract Research
Preclinical CRO
Drug Discovery
Virtual Screening
Protein Crystallization
Toxicology In-vitroADME
Medicinal Chemistry
Synthetic Developmental Chemistry
Pharmacology
Jubilant Biosys collaborates with the worlds leading pharmaceutical, biotech companies, academic institutions and research foundations.
Find out more about us at www.jubilantbiosys.com
The Position
Organization : - Jubilant Biosys
Designation Level: - Research Associate/ Sr. Research Associate (A3/A4)
Location: - Greater Noida
Department: - DMPK
Key Responsibilities
In Vitro ADME studies
Read and understand various in vitro ADME protocols
Conduct in vitro stability (liver microsomes, plasma and in any other relevant matrix, chemical stability) experiments for new chemical entities
Conduct the following in vitro ADME experiments
logP, logD, pKa measurements
CYP induction and inhibition assays
Permeability determinations (Caco-2, MDCK etc) in relevant cell lines
CYP phenotyping in purified enzyme systems
Solubility determinations (kinetic, thermodynamic, simulated fluids)
Bioanalysis :
Read and understand the bioanalysis sections in the study protocols
LC-MS/MS and HPLC-UV/PDA method development and validation (partial and complete)
Developing fit-for-purpose LC-MS/MS methods for routine in vitro sample analysis
Extracting data from the instrument, conducting bioanalytical QC and sharing of report with the stakeholders within the DMPK department
Experience in handling bioanalytical method development for various matrices with focus on in vitro samples; understanding to handle plasma, blood, various tissues, urine, faeces etc. is a plus but not mandatory.
Development LC-MS/MS methods for biochemical and cell based screening of NCEs is a plus but not mandatory
General LC-MS/MS and HPLC maintenance and troubleshooting
Data analysis and report generation:
Understand the quality of bioanalytical data
Conduct data analysis employing Phoenix WinNonLin software is a plus but not mandatory
Ability to calculate in vitro results/ parameters on excel spreadsheets
Report generation (excel format, word format and PowerPoint presentation) and sharing with the line manager
Generate reports in both GLP and non-GLP formats (based on the requirement)
Person Profile
Qualification: -
M.Sc /M.Tech (Biochemistry, Pharmaceutical Chemistry, Biotech background)
Master in Pharmacy (M.Pharm)
Experience: -
2- 6 years of relevant experience.
Experience in a drug discovery industry/ CRO in DMPK department.
Jubilant is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to age, ancestry, citizenship, colour, gender identity or expression, genetic information, marital status, medical condition, national origin, political affiliation, race, ethnicity, religion or any other characteristic protected by applicable local laws, regulations and ordinances.
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