Job Description

384539BR

Principal Scientist II, PKS PTM

India
About the role
PK Sciences (PKS) offers you this opportunity to make an impact, where 450 projects are straddling discovery through development. PKS is a global organization of about 300 associates, situated within Translational Medicine (TM), in Novartis Institutes of Biomedical Research (NIBR). It is an enterprise organization, unique within pharmaceutical industry, where one can work across both NIBR (Research) and the Global Drug Development (GDD) organizations to apply the scientific knowledge of pharmacokinetics, pharmacodynamics, metabolism and clinical pharmacology in advancing the drug candidates from discovery and clinical development through approval and beyond. Novartis portfolio consists of projects using several therapeutic modalities including small molecules, biologics, gene therapy and cell-based therapies. We are active in multiple therapy areas like Oncology, Autoimmune Diseases, Neuroscience, Musculoskeletal Diseases, Ophthalmology, Respiratory, Cardio-metabolic and Infectious diseases. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

Your responsibilities include, but are not limited to:

• Designs and conducts absorption, distribution, metabolism and excretion (ADME) research on compounds, drug agents and metabolites in pre-clinical and/ or clinical development.

• Using a physicochemical approach, attempts to compile various data such as absorption and excretion rates and drug agent half-life to establish pharmacokinetic profiles of new chemical and/or molecular entities as well as determining the optimum and safe dosage forms for compounds that have been determined to have indications for various disease groups.
• Responsible for developing protocols and/or preparing study documentation and findings to support domestic and inte national submissions of new drugs. May include modeling and simulation.
• May conduct studies using parametric optimization approach. Manages research related to absorption, distribution, metabolism, and elimination of drugs in both animals and humans for a therapeutic area, product line or program.
• Works closely with toxicology to document drug exposure in safety studies.
• Conducts bioanalytical research on drug agents and metabolites in clinical studies, including management of studies conducted in outside labs. Using pharmacokinetics, compiles data such as absorption and excretion rates to establish optimal and safe dosage rates.
• Serves as liaison with marketing, conducting analytical and kinetic studies on new dosage regimens and/or new dosage forms.
• Principal Scientist II: Participates in and/or leads multidisciplinary teams together with scientists from other units in Novartis; may work with external partners. Leads a lab and/or a project or technology area, integrating independent experimental work to drive achievement of goals with increasing efficiency. Collaborating across boundaries

Commitment to Diversity & Inclusion:
We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Role Requirements

• People Leadership
• Project Management
• Project Excellence
• Stakeholder Engagement
• Pharmacology / Toxicology
• Regulations & Guidelines

WHY NOVARTIS

769 million lives were touched by Novartis medicines in 2020, and while we\xe2\x80\x99re proud of this, we know there is so much more we could do to help improve and extend people\xe2\x80\x99s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.
We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what\'s possible, when we collaborate with courage to aggressively and ambitiously tackle the world\xe2\x80\x99s toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!
Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team\xe2\x80\x99s representative of the patients and communities we serve.
Join our Novartis Network : If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
Division
Novartis Institutes for BioMedical Research
Business Unit
Translational Medicine
Work Location
Hyderabad, AP
Company/Legal Entity
Nov Hltcr Shared Services Ind
Functional Area
Research & Development
Job Type
Full Time
Employment Type
Regular
Shift Work
No
Early Talent
No