Job Description

DMPK (PRE-FORMULATIONS)

RESEARCH SCIENTIST

Educational qualifications



M.Pharm (Pharmaceutics)/ Ph.D (Pharmacy)


Years of experience



8-10 yrs


Key Responsibilities






Read and understand client pre-formulation


requirements



Solid State and Solution State


Characterization (interpretation of DSC, TGA


and pXRD etc. data)



Solubility assessment in Aqueous and


Organic solvents simulated intestinal and


gastric Medias.



Bioavailability enhancement of compounds



Excipient Compatibility Studies



Preclinical formulation development of NCEs


for pharmacokinetic, toxicology, & in vivo


efficacy studies.



Ability to work with wide variety of


excipients, API and dosage forms



Hands-on experience in strategy to come up


with pharmaceutically acceptable salts for


NCEs and their characterization and


interpretation of the data to propose the


suitable salt.



Should know the know-how of various


formulations combinations to address the


solubility issues for various routes to perform


PK studies in preclinical species.



Should be able to develop dosage forms for


therapeutic areas like oncology, metabolic


disorders, inflammation etc.



Should be able to develop HPLC-UV based


methods for conducting formulation analysis


under GLP and Non-GLP modes



Good knowledge of chromatography



Preparation of documents such as SOP's for


DMPK (PRE-FORMULATIONS)

RESEARCH SCIENTIST

Laboratory instruments and reports for


preformulation studies.





Experience required






Good scientific knowledge about the role of


pre-formulation in small molecule discovery.



Basic knowledge of pharmacokinetics .



Knowledge of various excipients and their


permissible limits in preclinical and clinical


setups.



Handling of HPLC-UV/PDA



Liquid chromatography.